Endocrine Abstracts

Introduction: Maternal obesity is associated with increased risk of metabolic dysfunction in the offspring. It is not clear which physiological aspects of the obese state that cause this metabolic programming. Obesity causes many metabolic changes but also low grade inflammation. In this study, we have determined if increased low grade inflammation was present in obese dams compared to controls dams during gestation.Methods: Female C57BL/6 mice were fed ...

Generously supported by IPSEN)-->GH replacement (GHR) in adults has demonstrated to improve body composition, inflammatory cardiovascular biomarkers and quality of life. However, this benefit is uneven, and factors that stratify treatment response are required.According to current guidelines, low IGF-I levels in specific conditions provide strong evidence for GH deficiency (GHD). Nevertheless, normal levels do ...

Introduction: Childhood-onset hypopituitarism is an uncommon yet increasingly diagnosed disorder. As endocrinologists, we generally deal with the complexities of hormonal replacement and, when required, follow these patients to detect tumor recurrences. However, some causes of childhood- onset-hypopituitarism have comorbidities which can significantly increase morbi-mortality. We present the case of a 21-year-old girl who was diagnosed with ROHHAD syndrome.<p class="abstex...

Thyroid hormones (TH) are required for normal postnatal growth development in mammals. The physiological importance of TH becomes evident under the conditions of congenital–neonatal hypothyroidism (CH). If not treated immediately, CH has a profound impact on physiology and can permanently imprint neurological and endocrine systems, which, in turn, led to mental retardation, growth arrest, and metabolic disturbances. A delayed growth development or long-lasting influence o...

Introduction: Neuroendocrine lesions in the thyroid gland are uncommon. The differential diagnosis usually includes medullary thyroid carcinoma, paraganglioma and metastases. There are few non-conclusive reports of primary neuroendocrine carcinomas of the thyroid.Clinical case: A 49-year-old woman with a past medical history for familial hypercholesterolemia and right oophorectomy for mature teratoma with struma ovarii, was evaluated for a rapidly growin...

Objective: Zinc-α2 glycoprotein (ZAG) stimulates lipid loss by adipocytes and may be involved in the regulation of adipose tissue metabolism. We analyze ZAG expression levels in adipose tissue from a group of morbidly obese patients, and their relationship with lipogenic and lipolytic genes and with insulin resistance (IR).Design: mRNA expression levels of PPARgamma, IRS-1, IRS-2, lipogenic and lipolytic genes and ZAG were quantified in visceral (VA...

Hypopituitarism is associated with increased morbidity and mortality compared to healthy population. However, the factors influencing prognosis are still not well known.Objectives: To determine the causes of mortality in adult patients with hypopituitarism and compare the mortality rate with general populationTo identify the factors associated with mortality and survival.Patients: Two hundred and nine adult p...

Data on the quality of life (QoL) of patients with non-functioning pituitary adenoma (NFA) are sparse and conflicting. We have therefore evaluated the QoL in patients with NFAs followed-up in a tertiary UK referral centre and explored the impact of various factors. Three validated questionnaires (Short Form 36-SF36, Nottingham Health Profile-NHP and European Quality of Life Scale-EuroQoL) were offered to consecutive NFA subjects attending outpatient clinics over a 6-month peri...

Background: Dopamine agonists are first-line agents for the treatment of prolactinomas and sometimes are used in patients with acromegalia. There is evidence that these drugs, especially cabergoline, are associated with an increased risk of new cardiac valve regurgitation in patients treated for Parkinson’s disease.Objective: Our objective was to evaluate the prevalence of cardiac valve regurgitation in patients with prolactinomas and acromegalia tr...

Background: Endothelial dysfunction may have deleterious effect cardiovascular pathology in diabetic patients.Atrial natriuretic peptide (ANP) exerts beneficial effects on the cardiovascular system in part by exerting antioxidant activity. Recently it was reported that ANP is able to exert an antihypertrophic effect in myocitos at least in part due to inhibition of NADPH oxidase and superoxido generation.It seems that hyperglucemia...